As we have seen, this state of affairs is probably ushering in a condition of spreading suppuration of the coronary cushion, and considerable gangrene and sloughing of the skin.

When, from direct communication with the blood-stream, due to extensive hæmorrhage, bacteria from the outside gain entrance, this simple inflammation is further complicated by the formation of pus, or a limited gangrene of the keratogenous membrane.

On 20th August, 1715, he was attacked by senile gangrene, which gradually spread up the leg until on the 30th it became fatal.

If I can not bear the excision of a slight gangrene, how shall I sustain the operation when the wound is deep?