middle center centre midpoint midsection halfway inside interior heart hub midst core nucleus rear back opening thick body kindness metropolis bottom central open inland mainland region start minimum territory focus centrality eye epicenter end axis median locus base whole extremity torso capital nexus cynosure epicentre handicap disadvantage penalty drawback liability minus strike weakness subservience inferiority subordination impotence surrender yielding disfavour disfavor powerlessness incapacity unemployment lowland imperfection subjection servility inconvenience detriment impotency outside submission obstruction harm hindrance disapproval loss block injury waste inefficiency last misfortune lack blockage stop impairment debt hurt unfavorability distance surface underneath underside sole underpart undersurface foundation least