important : 94 noun collocations | Collocation dictionary
Thus an alteration in the PG E 2 /F 2α ratio plays an importantrole in mediating IDO's effects on cell growth and morphology.
Serving the needy has been an importantpart of our mission.
This only goes to show you one thing, which happens to be the most importantthing to know about investing: Trying to game the market in the short-term is the definition of foolishness.
Whether lipid-lowering therapy would provide incremental benefit if initiated immediately following an acute coronary syndrome is an importantissue as the risk of a recurrent adverse cardiac events is much greater in patients with unstable coronary disease than in the stable setting.
As both MMPs and COX-2 are importantfactors in tumor development [ 48, 49] IDO's role in tumorigenesis bears investigating.
Thus a potentially importantaspect of our work is the combination of motif discovery from modules via Gibbs sampling and generalization to the entire genome with Ahab.
Most of these tests are maintained in different locations and measured annually, thus offering desirable opportunities to address two importantquestions: (1) How does the genes interact with environment?
The complexity of integrated cellular systems leads to an importantpoint, namely that the properties of complex biological processes cannot be analyzed or predicted based solely on a description of the individual components, and integrated systems based approaches must be applied [ 8].
There are a number of importantfeatures associated with this vector that are illustrated in Fig 2.
While the detailed mechanisms for such a novel mode of regulation still requires many additional studies, so far we observed several importantsteps that may contribute to SNIP1 degradation.
Comparison of reprogramming events between M I and M II oocytes would bring about importantinformation to understand the mechanisms of nuclear reprogramming in reconstructed embryos.
Although the nocturnin gene appears to encode a potentially importantcomponent of the circadian regulatory system in the Xenopus eye, its position within or downstream of the circadian clock mechanism has not been determined.
An importantconsideration at the outset of these studies concerned the possibility that ectopic hCAR expression or adenoviral transduction might affect the normal development and/or function of T cells.
Here's how YOU can make an importantdifference in someone's life... Dear Friends of Literacy, We all share a special interest in reading.
There are many other importantareas where children, families, the elderly and disabled need our help.
While inflammation is an importantelement in the defense against infection, it can also contribute to cholestatic biliary diseases and cholelithiasis.
And, while clinical trial safety endpoints may be considered less glamorous, MIRACL's most importantcontribution may have been that high-dose statin therapy was not associated with serious harm, despite its use in the unstable setting.
They have the potential to shape our world and make importantdecisions that will affect us all.
I am sure you will understand my writing to you once more about the importantwork of the American Cancer Society.
Collagen-gel contraction by SPARC-null fibroblasts is not compromised An importantevent during wound healing is the contraction of newly formed granulation tissue by fibroblasts to bring together the edges of the wound [ 1 ] .
The most importantway to express that approval is through a financial contribution to support the work of the International Committee.
It's not a new story but it is an importantone to consider.
There was no evidence suggesting that local drinking water is an importantsource of cryptosporidiosis in this population.
Implications for Myo1c activity The Ca 2+-dependent change in interaction of calmodulin with IQ1, the IQ domain closest to the motor domain, has importantimplications for Myo1c mechanochemical function.
We suspect that the most importantreason for the existence of a threshold signal is related to the formation of hybridization networks at these spots, which are also known as hyperpolymers [ 9 ] .
Development of the parallel plate flow chamber that simulates the conditions of physiologic flow has been an importanttool for dissecting the molecular events occurring between flowing leukocytes and endothelium [ 3 4 5 6 7 8 9 10 11 12 13 ] .
Making Nice As I understand it, when political scientists and sociologists refer to a society as "civil" they are citing the many importantfunctions that are performed by voluntary, intermediate institutions.
Aside from the major finding that screening did not reduce lung cancer mortality, several other importantfacts were uncovered.
I have already had occasion... to allude to an unfortunate habit which Prof. Skeat has of writing importantnotes without first consulting the full and accurate Indexes of N. & Q.; and I am very sorry to be obliged to renew my accusation.
Our results confirm that the importantchanges are indeed associated with subunit B.
Clinton, by contrast, is someone whose brain (unlike other parts of his body) seems always to be deployed in just the right places, shining light on an astonishing variety of importantmatters.
While rehospitalization for recurrent myocardial ischemia is an importantdeterminant of quality of life and health care costs, other important endpoints were not significantly affected (eg, death, myocardial infarction, resuscitated sudden cardiac death, worsening heart failure, need for coronary revascularization, etc).
While the LAT labels Vladimir Putin's visit to Chechnya a presidential "campaign-style tour" and the NYT calls it "unexpected," the Post relates that the new president had planned the trip months ago, long before Boris Yeltsin decided to step down (this importantdetail probably pushed the story off the Post 's front page).
No matter what we do that day, I always seem to learn an importantlesson."
It holds an importantcollection of classical and ancient works of art of Asian and Islamic origin.
Dear Mr. and Mrs. Name: Would it surprise you to learn that some importantpeople like Rembrandt, Rodin, Rubens, Seurat, Picasso, Cezanne, Van Gogh, and O'Keeffe, rely on your support of the museum's Annual Operating Campaign?
Signifies one of the most importantstories of the day, according to that paper's editors.
Additionally, practices that considered "prior user testimony" important in the selection process were 1.39 times more likely to agree with the scheduling subscale than those practices that did not consider prior user testimony as an importantinfluence.
But the description that each of two people has a mole on the forehead, an uncommon feature, is an importantpiece of information that can be used to establish a link between the two people.
Joan Pittock (Aberdeen) undertakes the importanttask of evaluating Boswell as a critic.
Much progress has been accomplished in determining the molecular steps that lead to a better understanding of murine T cell progenitor commitment and selection of the functional repertoire, which has gained importantinsights into mechanisms of CD4/CD8 lineage commitment (reviewed in 31).
Another equally importantmessage is that no matter how carefully we try to craft categories of giving, human behavior refuses to be comprehensively categorized.
Upstairs is the Musée de l’Histoire de France, which displays a number of importantdocuments, including Louis XVI’s diary with its famous entry noting, “Rien” (“Nothing”), for 14 July 1789.
Synonym differentiation was evidently--and rightly--seen as a crucial task and the thoroughness with which this task was carried out is one the dictionary's most importantassets.
The sequence traces used in these assemblies are available from the GenBank trace repository and Release 3 offers a high-quality sequence for comparison, providing an importantresource for testing new WGS assembly algorithms.
The ability of this assay to genotype any SNP regardless of the base pair involved is an importantadvantage over assays based on primer extension such as PCR.
I know that as an importantbusiness and community leader, you are frequently deluged with requests for funds from worthwhile organizations.
Any or all of those assumptions may be wrong, of course, but in pointing to the discounting process in particular Greenspan did somethingimportant, which was get away from the simple idea of "irrationality" and move toward a more rigorous analysis of what's been happening.
The Dialectics of Dialects Dear Dennis, Judging from the responses to our exchange, we've skipped over some of the issuesimportant to most people, so perhaps we should go over dialects before we return to some recent headlines.
Although SPARC is expressed in fibroblasts and macrophages at wound sites [ 18 ] and functions in many processesimportant to wound repair, the role of SPARC in wound healing in a whole animal has not yet been studied.
Along these lines, it has been shown that RSV activation of chemokine gene promoters involves multiple inducible transcription factors including AP-1 [ 52 53 ] , which is also a redox sensitive transcription factorimportant in chemokine gene expression [ 28 36 54 ] .
Recent mutational analysis of recombinant PP5 has identified sequencesimportant in autoinhibition [ 19 ] .
Identification of over-represented sequence motifs in core promoters Core promoters are known to contain binding sites for proteinsimportant for transcription initiation, and our first analysis of the sequence content of our set of 1,941 core promoters was to assess the representation of two well-established core promoter sequence motifs, the initiator (Inr) and the TATA box.
Were you about to turn the virtual page, figuring that this couldn't be about anythingimportant?
The SMYD1 proteins are transcriptional regulatory proteins with chromatin-remodeling activitiesimportant in cardiac tissue, muscle and T lymphocytes [ 31 32 33 ] .
Giant vacuoles (structuresimportant for aqueous movement from the TM to canal lumen) were clearly observed indicating that SC was functional at P14 (Figure 3A).
The LEF-dependent luciferase assay in S2 cells is versatile, dynamic, rapid and can provide important clues about interactionsimportant for Wnt signaling.
Whatever the technical merits of the government's interpretation of the decree, you have to wonder whatimportant public interest will be served if the government's case succeeds.
In summary, practices that considered value important, that did not consider compatibilityimportant, that selected managed care software, that spent less than $10,000, or that provided learning time during implementation were more likely to perceive that the software had improved the financial analysis process than were other practices.
Why are formal complaintsimportant?
Based on previous reports, disintegration of the cyclin/cdk complexesimportant for DNA synthesis is correlated to E2F-1 expression level [ 1, 5].
Civil society based on formal association is seen as a tool to mediate tensions between citizens and the state and in this way reduce risks for foreign capital and provide stability, two necessary environmental conditionsimportant for western capitalism.
Is the controversyimportant?
A few authors have noted that the fish consumption effect, despite being negatively associated with birth size, is small in comparison to other covariatesimportant for fetal growth and development [ 12 24 ] , which is more in keeping with our findings.
The customer views collected allows the purchase criteriaimportant for these customers to be revealed, so that the key purchase criteria can then be incorporated in a Customer Value questionnaire.
Cell culture and tumorigenesis model A weakly immunogenic lung cancer, Lewis lung carcinoma (3LL, H-2 b) obtained from ATCC (CRL-1642, LLC) was utilized for assessment of cytokinesimportant for SLC/CCL21 - mediated anti-tumor responses in vivo .
Why is decompositionimportant?
Two recent observations lend credence to the idea that genomes may be divided into domainsimportant for controlling the expression of groups of adjacent genes.
Why are Vitamins A and Eimportant?
Why is a ge-free environmentimportant for organic agriculture and horticulture?
This will be achieved by ensuring everyoneimportant in each client's life is included in planning and decision-making.
What Gilder was pointing to here was in factimportant.
Next: Lessons from Leigh: successes, mistakes, failuresimportant for others to learn from.
Histopathological Analysis Various histological featuresimportant for the differential diagnosis of A-GVHD were selected after review of literature [ 12 13 14 ] .
Before 9/11, Treasury did not consider terrorist financingimportant enough to mention in its national strategy for money laundering.
Why is a floodimportant to the Ancient Egyptians?
Not only is the content of a fish foodimportant, but also the way the food is prepared is a factor of great significance.
Is the image of the functionimportant for your family especially, or is it more a fun day to share with friends?
Why are saline soil habitatsimportant?
Main streets such as Queen Street and Duke of York Street recall the monarchs and individualsimportant to the British Crown.
Why are invertebratesimportant?
Why is this investigationimportant to people?
Another investmentimportant for old age is friendships.
We hypothesize that at the household levelimportant factors may include house type, household wealth, household density, and house location.
Is the light that comes out of a Rife machineimportant?
When Giuliani vetoed Talk 's party site and told the press it was "unimportant" and "irrelevant," all he did was make the magazineimportant and relevant.
Why is risk managementimportant?
Is the metronome markimportant?
Knowledge and exposure to Use Case tools and methodologyimportant.
Conclusions Why is protein/proteome modellingimportant?
A few G-protein coupled receptors such as cannabinoid receptor, GABA-B R2 receptor, and olfactory receptor-like protein (SCRD-9), as well as moleculesimportant in signaling such as Galpha(olf), Guanine nucleotide releasing factor, and CAM kinase I beta 2, CAM kinase II beta, and PKC beta were also identified to be expressed more in the dorsal spinal cord.
Although the international media focused on the damage caused in Assisi, much of the region suffered structural damage, and many frescoes and monumentsimportant throughout the region were severely damaged or destroyed.
Why are networksimportant for schools?
I do not consider the word noshimportant enough, or for that matter frequent enough, to have been included.