The thyroid gland, the pituitary gland, the adrenal glands, the thymus, the pineal, the sex glands, have yielded secrets.

Little more than a hundred years ago, it was observed that certain organs, like the thyroid body in the neck, and the adrenal capsules in the abdomen, hitherto neglected because their function was hopelessly obscure, had a glandular structure.

It was soon found that the cells of the more familiar glands, like the sweat or tear glands, resembled the cells of the more mysterious structures named the thyroid in the neck, or adrenal in the abdomen, of which the function was unknown.

Besides, there must be a minimum activity of the thyroid, adrenal and pituitary glands.

For normally, with feminine puberty, there is an increased activity of the thyroid, the posterior pituitary and the adrenal medulla.

In the male, the ripening of the testes is accompanied or perhaps preceded by augmented function of the adrenal cortex and the anterior pituitary.

Ovary and adrenal medulla and posterior pituitary and thyroid predominance constitute the feminine formula.

Testis and adrenal cortex and anterior pituitary predominance comprise the masculine endocrine directorate.

If the sex glands themselves fail, as occurs usually in most women sometime in the forties, the thyroid-pituitary-adrenal association must readjust itself to the new development.

Sexual precocity in boys may be produced by a premature overactivity not only of the specific reproductive organs: the testes, but also by an early excess of secretion on the part of the cortex of the adrenal gland or the pituitary gland, or by a too early involution of the pineal or thymus.

When such abnormalities of adrenal, pituitary, thymus or pineal occur in girls, it is the masculine streak in the hastening of growth that is made manifest.

The degree of masculine trend in a woman is a crude measure of adrenal domination, the degree of feminine deviation in a man is roughly proportional to the amount of pituitary influences in his make-up.

The masculine personality, the combination of masculine, e.g., adrenal cortex and gonad internal secretion predominance, is built for aggression.

It seems as if, once successful impregnation has been achieved, the feminine organism adrenalizes itself, makes itself more masculine and less feminine, inhibiting the posterior pituitary and the adrenal medulla, as well as the ovaries.

This in turn stimulates the thyroid and adrenal medulla.

So a cold climate, which necessitates a more voluminous hair covering for an animal, will evoke a hypertrophy of the adrenal cortex.

The adrenal cortex makes for pugnacity, temper, animal courage, irritability and anger reactions.

An environment which tends to encourage the masculine traits in her, to arouse repeatedly her pugnacity and combative decisions in the more rapid give and take of the masculine world, will rouse the adrenal cortex to greater activity, and so make her face hirsute, her attitudes aggressive, and perhaps render her sterile.

While the ovary, stimulated by the thyroid and the adrenal medulla, is the chief determinant of the sex instinct, to the posterior pituitary must be credited the chief hormone of the maternal instinct.

The adrenal type may not be able to respond with the necessary enlargement of its cortex which is normal for the needs of gestation.

Of adrenal insufficiency, failure of the adrenals to hypertrophy sufficiently in pregnancy, little is known.

For there is the most curious resemblance imaginable between the cells of the adrenal cortex and those of the corpus luteum, some day to be completely explained.

The adrenal centered will have a high blood pressure and masculinoid traits, the adrenal inferior will have a low blood pressure and suffer from a constant weakness and fatigability.

The adrenal centered will have a high blood pressure and masculinoid traits, the adrenal inferior will have a low blood pressure and suffer from a constant weakness and fatigability.

The male's attitude, aggressive pursuit, is instigated by the compound adrenal and gonad endocrines.