The Italic letters were invented by Aldus Manutius at Rome, towards the close of the fifteenth century, and were first used in an edition of Virgil, in 1501."Constables Miscellany, Vol.

ALDINE EDITIONS, editions, chiefly of the classics, issued from the press of Aldus Manutius in Venice in the 16th century, and remarkable for the correctness of the text and the beauty and clearness of the printing.