He summed these up in 1891 as follows: "All the tissues, in our view, are modifiers of the blood by means of an internal secretion taken from them by the venous blood.

As this was deceiving her aunt she felt obliged to put a blot on her head 'scutcheon, in the form of a black record, but she was so inwardly amused at it that her appetite improved of its own accord, and Aunt Phoebe remarked in a gratified way that she had never known the equal of Mullin's Modifier as a tonic.