Several important signaling molecules, including activated TCR, LAT and LCK are present in organized raft-type microdomains, and integrity of these microdomains is necessaryfor T cell receptor signal transduction [ 36 37 ] .
Pooling of RNA was necessaryin some cases because most of the RNA from some samples had been used for other purposes.
In order to enhance AA release in cells containing endogenous cPLA 2 , it is necessaryto over-express the enzyme several fold as previously reported [ 16 ] .
Elsewhere in the Middle East, Egypt's Al Ahram daily said in an editorial that "now that it has been revealed that the U.S. has used UNSCOM for spying purposes, it has become necessarythat the international organization take a firm stance by which to prevent any of its organizations being used for purposes other than those mandated."
However, it is not always necessaryif urine flow is minimal and can be managed with absorbent pads or surfaces.
Finally, due to the rapid decay of gene expression following maximal activation, this system can be easily titrated for the duration of the induction necessaryby using slow release formulations such as ALZET mini pumps [ 18 ] .
Although the abnormal carnitine ester present in the proband is elevated in organic acidemias and is not usually present in mitochondrial cytopathies, we speculate that due to compromised ATP synthesis, secondary alterations may be generated in these patients by changes in mitochondrial protein synthesis, decrease in Krebs cycle intermediates and increased free radical formation, that could be responsible for a secondary impairment of mitochondrial biotin dependent carboxylases, but further elucidation is necessarybefore we could arrive to a conclusion in this regard.
In particular, the need for scale independent methodologies becomes even more necessaryas the limitations of conventional Markov chains are increasingly noted [ 6 ] .
This situation would have occurred when the BCS code was actually used for a diagnostic biopsy and the subsequent surgical treatment was a mastectomy or in situations where a lumpectomy was first selected, but a mastectomy became necessarybecause pathological examination revealed cancerous cells in the margins of the excised tissue.
Direct contact with the skin is necessarywith traditional laser Doppler probes, and there are frequent difficulties in maintaining the same point of contact, making sequential measurements open to inaccuracy [ 27] furthermore, pressure may influence local perfusion itself [ 18].
We then searched for homologs of these selected regions in Anopheles gambiae using WU-BLAST of the Dm sequence [ 42 ] , extending the returned sequences as necessaryon their 5' and 3' ends to make 100-nucleotide windows equivalent to the queried sequence.
For the small number of cases (N = 8) for whom lymph node involvement code was unknown, we considered this the same as no lymph node involvement because the tumor size was so small for these cases that a lymph node dissection was not considered necessaryat the time of this study.
Bronze divisions, once defined at the beginning of a year will apply for the remainder of that year, but may be redefined as necessaryfrom year to year.
This is particularly true given the significant associations of both body mass index and allograft rejection with hospitalized poisonings in this analysis, which may indicate that more complex and individualized methods of medication dosing may be necessaryafter renal transplantation than are currently used.
However, because their spinning frames are all locally made, WRONZ Senior Scientist, Dr Jim Lappage, spent two days at the mill in May advising them on modifications that would be necessaryso the Spinbulk process could be run successfully.
In the High Court, Dr Little was convicted of'failing to provide the necessariesof life thereby endangering [Leana Steven's] life or permanently injuring her health.'
Pooling was necessarydue to the small volume of vitreous collected, and each pool consisted of 2 to 4 eyes (see Materials and methods).
Midwifery Skills for Emergencies is a comprehensive refresher in the midwifery skills necessaryduring perinatal emergencies in primary care settings.
A referral from your GP is not necessaryunless it is for an old ACC claim.
Ask why, how, how much, and as many other questions as you feel necessaryuntil you are completely satisfied that you are getting the best deal possible.
The pump unit would be extended by one metre and the opportunity would be taken to refurbish the pump as necessarywhile it was removed from the structure.
The independence of C/EBPα regulation of proliferation from its intranuclear localization may even be necessarysince we have recently determined that pituitary cell differentiation is associated with the dispersal of C/EBPα from peri-centromeric heterochromatin by the pituitary-specific transcription factor Pit-1 (J. F. E., M. A. Kawecki, F. S., R. N. D., submitted).
Most contributors agree that sex and children are desirable but not necessarywithin the relationship; all agreed children should be the primary consideration in cases of divorce.
The president reiterated that China would use force if necessaryagainst the Taiwan "separatists" and against "foreign forces which try to impede the reunification of China."
I having said that England was obliged to us for gardeners, almost all their gardeners being Scotchmen; Johnson: "Why, Sir, that is because gardening is much more necessaryamongst you than with us, which makes so many of your people learn it.
Job descriptions and where necessaryexcept a high acute workload when vacancy becomes known.
I have no desire to belong in that as I see it as an empty mirage, devoid of substance, albeit serving its own necessarythough convoluted purpose.
Conservation of these habitats and species should depend upon active intervention by the management authority, if necessarythrough habitat manipulation (c.f.
The procedure is used for a very small percentage of late abortions, and nothing makes it especially necessaryover D and E. In fact, none of the obstetricians I talked to had even heard of the technique until it became a hot political topic.
In these circumstances further medical referral to other disciplines would not have been considered necessaryunder those circumstances."
I wish to signal to stakeholders at this time that I propose to consider a number of options for giving effect to this outcome, including if necessarysomeadjustmentof the TACC recommended in the IPP.
"In the absence of any kind of certainty, a clear understanding of the mechanisms and direction of change becomes critical knowledge.The faster firms move, the more necessarythiskindof future reality check becomes.